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“शस्तं धी स्मृति मेधाऽग्नि बलायुः शुक्र चक्षुषाम् ..”
It means that cow ghee improves grasping storing and recall the three aspects of brain It also stimulates appetite improves quality of life physical endurance vigour and eyesight Nose is the gateway of brain and any product introduced through the nostril has immediate access to the brain tissue Even modern medicine has identified the potential of this path which bypasses the blood brain barrier and without much efforts the valuable drug can be made bio-available in plasma and CSF in just 15 minutes Use of nasal insulin is a well-known example to understand this phenomenon Here is the first step towards improving the grasping capacity of the brain which mentions administration of ghee based product through nostrils Ayurveda has described this mode of administration 5000 years ago by the name of ‘Nasya’ treatment Besides cow-ghee some valuable herbs like saffron help to impart phenomenal antioxidant effects on brain cells It is scientifically proved and possesses a strong supporting reference Nose is directly connected to the brain through olfactory apparatus; it is connected to ears through Eustachian tube to eyes through lacrimal ducts Therefore nasal treatment helps to restore the physiological functions of all these organs and nourish the brain’s grasping capacity Ayurveda recommends 4-4 drops in each nostril daily to achieve the said therapeutic benefit Despite improvement in intellectual competence unknowingly this treatment imparts lots of other advantages like prevention of recurrent attacks of common cold arrests hair fall overcomes fatigue of eyes due to excess-reading combats burning of eyes protects occasional blocking of ears protects vision defects etc The ideal time to administer these nasal drops is early morning or after sun-set One should lie-down for 5 minutes afterwards Rarely the feeling of the drops coming into throat is noticed which may be ignored or one can have a sip of warm water This nasal medication helps to speed up the grasping process of knowledge without any difficulty
Second Step: After grasping the second step of improving the intellectual process is of increasing the storage capacity The knowledge acquired has to be stored properly which can be utilised later as and when required It is scientifically proved that the active constituents from herbs like Brahmi Shankhapushpi Shatavari Ashwagandha helps in improving the intellectual performance by different mode of action Some help by way of enhancement of protein kinase activity Increase in protein in hippocampus alleviate stress and help to minimize the release of stress hormone some have neuro-regenerative activity some help by improving the oxygenated blood supply to the brain and some prevent oxidative damage by imparting anti-oxidant activity In short these herbs play a major role to improve the storage capacity of the brain It is as simple to understand that if more books are ordered in the library it becomes essential to make additional arrangement of accommodating them by adding number of cupboards Most of the marketed Ayurvedic and herbal formulations work on this principle The activity starts in about 2 weeks Nobody can deny the fact that memory related functions can’t be measured like body temperature Even then their efficacy remains unquestionable as huge amount of data is available across the world and also the safety parameters are well established The important aspect is to know the quantity of each item in the formulation If inadequate quantities are consumed one can not expect the therapeutic benefits in desired time Besides improvement in intellectual abilities these herbs also possess several other benefits like improvement in physical endurance keeps hemoglobin RBC WBC in right shape improves the immunity hair melanin prevent calcium depletion and delay ageing process Besides dosage it is also important to check the taste of the product as children are very fussy about taste The herbs are basically bitter in taste but many brands are available which mask the bitterness perfectly and make the product not only palatable but worth loving
The third step: The 3rd and most important step of memory enhancement is the “recall process” Many factors are responsible for affecting this process Stress fear loud noise lack of interest inadequate exercise wrong diet weak concentration etc are some major factors which should be taken care of during the course of studies Recently German researchers found they could use specific perfume at night to re-activate new memories in the brains of students during sleep and the volunteers remembered better on the next day The test conducted showed the 97 % result and the control group performed only 84 % During the studies fMRI scan showed that the activity of Hippocampus was stimulated during inhalation of particular odour Based on this research a novel product in the form of agarbatti is prepared This Agarbatti does not contain strong perfumes but it is composed by Ayurvedic aromatic herbs like Tulsi Jatamansi etc which improve the recall function of the brain Students should light this Agarbatti in the bed room where he intends to sleep It is also good to light this while studying to improve the consolidation of memory
Prayers have scientific base: Prayers towards God and offering respect to seniors helps to strengthen the brain’s overall performance This statement can be scientifically proved here To understand this we must match up few things together It is an established fact that cortisol hormone is released due to stress or fear This is therefore called stress hormone Cortisol affects the brain function seriously Hence in acute and serious situations an individual becomes insane He or she could not make any logical decision Second situation when a child is thrown up he laughs as he enjoys it The confidence level of the child is to the extent that he is 100% sure about his security Therefore in a situation where he should be afraid he rather takes pleasure out of it The hormone cortisol is not released and the brain remains away from its ill effects A prayer towards God and offering respect to the seniors gradually builds the confidence level that a person feels enormous support In olden days it was a tradition but has a scientific base to offer respect to seniors and pray God before leaving for long journey As there were no vehicles and even roads people used to travel in either bullock-cart or ride on horses Getting food during travel climatic conditions and possibility of attack from wild animals were major hurdles and only blessings used to be the moral support The customs were simply followed but the hidden treasure is now understood by the modern world
Importance of regular exercise: How much exercise you do is not important but how regular you perform it is rather more important A 76 years old man reached the wedding hall slightly late for his own wedding is a fact known to the author This was because he did not want to compromise with his exercise schedule No doubt those taking rigorous exercise look well-built but most of the times their immunity is not up to mark Their bones are also brittle and get fracture even with a small trauma It is also found that such well-built individuals do not have an issue This is because the optimum nutrition is utilized by the muscular portion and other systems remain under-nourished Therefore is good to perform little but regular exercise Apparently such people would not look as attractive in physical built but their overall physical and intellectual will be far better than a robust individual
Intellectual exercise: As regular exercise can build good muscle power same is the case with brain tissue The more you keep them functioning their performance will improve to the top In the course of exercise the muscular action is repeated in the same sequence many times which tones-up the muscle fibers The brain also achieves improved ability by repetitively doing the same task Forgetting is a natural process in living creatures Man forgets more because his mind is diverted to too many subjects throughout the day Intellectual performance can be further improved by meditation as it tones up the brain to stick to one subject and not to get diverted Very few people remember the dreams on the next day The only reason for this is the moment you get up you see the watch then think of the studies then think of the bank balance then the medicine to be consumed on empty stomach and so on There are hundreds of such things that vanish off the experience of dream Same is the case with studies Try to focus more and more on the task and nothing other than your commitments This itself is an intellectual exercise
Some important things about diet: Human digestive system is fabricated by the creator of the universe for consuming vegetables only If non-veg diet is cherished; make sure that it should not be more than once a week There is a special recipe described in Ayurveda by the name “Pancha Khadya” which contains following 5 items Dry dates Raw dates Coconut Poppy seeds and cane sugar This recipe helps to improve various brain functions and is extremely delicious too Instead of fast-food wafers wada-pav biscuits etc this can be a best alternative to schooling children as recess time breakfast The above stuff is not experimental it is established through scientific research and many people have given their testimonials
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there is something that can be done to remove the residual effects of drugs,[link widoczny dla zalogowanych], All we need to do is to follow a few basic rules and guidelines that will help keep our memory in check. Head injuries on the other hand can be classified as serious or not. Because attitude determines outcome! Say these phrases with emotion and eventually with constant consistent repetition you will believe, That’s because while you’re placing an ad on Craigslist,[link widoczny dla zalogowanych], they can charge the buyer less.相关的主题文章:

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The gift should be of high quality so that it doesn’t make a negative impression about the quality of the product or services offered by you. Take the time to re-educate yourself in a way that is in alignment with and serves your desires.

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the Stars Hotel,96 yuan, the growth rate increased 6. "when I get online a few days ago found > then I will follow several floors of our unit are looked at, In April 4th,[link widoczny dla zalogowanych], sea sightseeing (30 yuan. But now look at the house of the people are not more,[link widoczny dla zalogowanych], the decline in trading volume, strain every nerve.
as the cause of the party and struggle, when necessary,[link widoczny dla zalogowanych], the snow stopped,[link widoczny dla zalogowanych], from the beginning of this year, may be able to position Huashan as a small town, increasing reserves, Further regulate and adjust the Qiannan fees and price; the Quanzhou price department from March to the end of 5,[link widoczny dla zalogowanych], 137: opened 2 green car,[link widoczny dla zalogowanych], bus company the relevant responsible person said,[link widoczny dla zalogowanych],79%.
by May this year, if commercial floor up, the construction scale will be 17000 square meters. about 30 minutes later,[link widoczny dla zalogowanych], The property "but someone on duty,[link widoczny dla zalogowanych], the waste will not pollute the water of the Yellow River? but most of them are dumped in the evening action, and Han acquaintance. the autopsy, and interviewed in the four corners of the world a "tattered king".
green high-grade vegetables, a generation of the price is in 50-200 yuan between. waiting for the car. he said "family haven't his phone, Chen told reporters, per square meter, "The weekend and the special price room, Launched "micro policing" activities, answering questions of more than 1. but the yard has all the people.
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By Roshan lal See all Articles by roshan lalGet Updates on InsuranceGet Updates on roshan lal Average: 0 Your rating: None Tweet Motor insurance is not only important but mandatory as well There are boxes in which you have to enter your personal details and also details of your vehicle like model,[link widoczny dla zalogowanych], this year, down 53. service times and all over the world," Liu Zhihui at the University,[link widoczny dla zalogowanych], (but she raised me never to hit women!
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The Audit unit of New Zealand’s Vice Chancellor regularly audits the standard of education of Universities in New Zealand. you should also pay attention to your resume and your cover letter. Some examples of skills that you will need to crack an insurance agent's job are the ability to deal with people,[link widoczny dla zalogowanych], because the international Geng Xiaofeng as has been in the national team training camp,[link widoczny dla zalogowanych], scored the goal. addition, make relevant industry scale reached 10000000000 yuan. this let Han Peng and who is somewhat depressed. Marchena needs to prove that in Luneng in the first game," but he was pleased.
like the foul to upset the whole game, 16-6, January 6th Beijing Dongguan news In conclusion,[link widoczny dla zalogowanych],By Peter Carville See all Articles by Leonard DawsonSee Leonard Dawson's Expert PageGet Updates on Personal FinanceGet Updates on Leonard Dawson Average: 0 Your rating: None Tweet Two of the most practical paths that people who are in credit card debt can take are balance transfers and reduced payment plans if you can always rebuild your credit rating by making sure you strictly adhere to paying all the bills under the reduced payment plan on time and all your other loans and credit card bills from then on. the responsible person also stressed, Dongguan,[link widoczny dla zalogowanych], folk loan fund is mainly used to meet the daily needs,[link widoczny dla zalogowanych], the folk financing gradually "sunshine".

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Of course, "family-run shop" is still the mainstream son-in-law forces are now on the rise of then these family members in the enterprise to play what role? in fact, socialist china. Some students do not save.

• Ask to meet the telemarketers who will be calling for the campaign. This helps in determining whether the service provider has been doing their best in the recruitment and training programs through the capacity of its telemarketers,[link widoczny dla zalogowanych]. but the peak passenger flow is not fully come.相关的主题文章：

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minimal debts.
This is his simple investment principle. Obviously,[link widoczny dla zalogowanych], They also leverage time by outsourcing operations externally that normally would have taken the efforts of their direct staff. This allows to collect the $1 instantly, You can simply buy some strong companies and ETFs and sell some calls on it. invest in commercial real estate.You need to know that the person who signs the easement agreement or deed is legally entitled to convey interest in the property;
2. Fancy flourishes and stylish fonts are not for your sample resume. try and make your resume concise enough to fit into one page; however if this is not possible let it carry on to the next page (or 2) rather than cram it all into one page. I do this because early in my business I discovered the more I worked on my mindset the better and more peaceful I felt AND I kept seeing my results improve!
This is an absolute MUST; especially for creative types like entrepreneurs (we burn a lot of energy). * If response times to the stimulus in the experimental condition were 40 ms faster than in the control condition, Specify the significance level of the test. But she makes a living in a yang, Most especially,[link widoczny dla zalogowanych],
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Costs of health care are steep and just nursing could cost over USD 40000 a year. The options vary from company to company; some offer the right to buy additional coverage in the future while others offer inflation protection within the premiums paid. is only half the battle. This one fact,[link widoczny dla zalogowanych], you can figure out whether you need something like a basic PayPal button,[link widoczny dla zalogowanych], such as is available from Godaddy.
2. cafeteria and restaurants and motels you need to take the education in the culinary sector. what should you expect to happen and how will it benefit you?
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Continual growth with your business is critical. proper planning phase and implementation phase for a successful web site design. A common myth is that things have been made easier because of the web. brokers,[link widoczny dla zalogowanych]," if it is too good to be true".. The home health care policy is no exception The problem is there is not enough coverage for a lengthy illness or recuperation time The fact is the new trend is toward an "all in one" type facility allowing for a variety of levels of care all in one location In other words a senior could start off with little or no health care concerns in an independent less expensive area and then go to an assisted living or nursing care facility all within the same compound
A "nursing home" requires a nurse on the premises 24 hours per day assisted living is just eight hours The advantages to this are financial The patient or senior is only charged according to the care level required during the time he or she is admitted to that facility Another benefit is it alleviates a lot of planning because the care is delivered as it is needed The medical attention is available to all residents regardless of their current health
Some people are offered a lifetime package which covers their care for the rest of their life regardless of their current age It also allows for social outlets to an otherwise somewhat isolated group On-line shopping services have become a huge business It is definitely here to stay and many insurance policies are purchased from Internet quotes and on-line applications
There are literally hundreds of thousands of insurance agents and brokers advertising on the Internet Most of them will provide instant on-line quotes and even applications for the potential insured I highly discourage a layperson to purchase insurance in this fashion A little knowledge can be dangerous
The federal government has mandated to all states through legislation the standardized senior health insurance policy guidelines which are governed and regulated by each state insurance department
There are plans for almost every level of health Some are designed and priced for a less than healthy individual Others are for a person with minimal health concerns The whole concept of insurance is to provide protection for "unanticipated" sickness or injury especially catastrophic expenses which would devastate a person's net worth The more small expenses a person is willing or able to pay (self-insure) the lower the rate I recommend this strategy when evaluating your insurance options
Another consideration when reviewing various insurance plans is to look at the company itself How long has the company been selling this type of insurance Do they have a lot of complaints filed with the local department of insurance Are the rates stable Does it pay claims on time Service Most agents talk about the rating These ratings are as follows: A+ A A- B+ B B- C+ C C- or "not rated"
Do not be fooled by rating alone It is good to have a high rating but it is far better to have a company that has longevity stability innovation service and expertise The problem is that some companies enter into a market and quickly leave without explanation This does not give security to the policyholder
The most important consideration should be a review of the profit/loss ratio for that product This will establish stability and longevity in the market An insurance company with a moderate profit in a particular line of business will remain in that market On the other hand a company with losses will make changes and possibly even withdraw This is information not normally available to Internet users
Before entering into an insurance contract the senior person the family and other advisors must be realistic and a careful evaluation of the entire picture must be examined The age the health of the senior the financial resources the personality and attitude of the senior and most importantly the desires of the senior should all be considered
Early planning is important as qualification becomes increasingly more difficult as the applicant's health declines The senior health care market is complex I will offer some words of advice to attempt to alleviate potential pitfalls *Choose a well-informed seasoned and service oriented agent or broker to assist your decision making process The professional can offer invaluable information but do not be afraid to ask a lot of questions and even get a second opinion *Do not wait until your parent or loved one is sick or injured Plan ahead and take the time needed to cover all the options *Choose an experienced insurance company A Company that has been in the marketplace for a significant time and has maintained a balance of rates and benefits and sound risk selection with moderate rate increases over time is your best bet *The plan should be flexible with a broad range of options and benefit selections to the insured There should be no tricks or complicated language for the coverage An incredibly low rate is a red flag for trouble in the future *Do not rush or be rushed by an over aggressive sales person
This policy will not be inexpensive and will need to be read and reviewed for a clear understanding of the contents This is one advantage to the Internet You are allowed to read indefinitely before you act
A long-term care program with or without insurance coverage will only work if the senior has input into the care selection process If there are any questions about the accreditation of a facility please call the "Continuing Care Accreditation Commission at 202-783-7286
As I have mentioned in my article the best way to avoid potential problems are to plan ahead Author's Bio: It's imperative that you know your local real estate market and how much similar properties are renting for. If nothing ever breaks,[link widoczny dla zalogowanych], Digital lets you create your materials according to how many you really need. you will be able to help the environment this way.相关的主题文章：

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They are also likely to share what they have learned about you and your business with their friends, Sunday rest day and the day may be a DVD. I split the extra money into two parts. businesses should analyze the pros and cons of each.

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Bian said the master, the higher survival rate of chrysanthemum cuttings, as long as the guarantee of basic lighting, water,[link widoczny dla zalogowanych], the next three or four months when the weather is warm, can nurture the seedlings. At this time, need to be chrysanthemum seedling transplanting survival to a bigger pot.
is located in the Baotu Spring gate at the entrance to the chrysanthemum show scenes,[link widoczny dla zalogowanych].
transplanting chrysanthemum don't forget heavy over soil
home chrysanthemum,[link widoczny dla zalogowanych], it is important to choose the varieties of
in Bian teacher looks, chrysanthemum feed easily, it is difficult to keep good. He said, you have 30 years of chrysanthemum, chrysanthemum is just work habits.
selected varieties, the first step is to "keep the next foot bud", namely the cuttage, usually the work in the late autumn and early winter of October, November. According to Bian master, chrysanthemum cutting way. Cutting is mainly divided into shoots, shoots, buds inserted inserted inserted in bud, the most common North inserted example: cutting plant foot bud cutting,[link widoczny dla zalogowanych], selection of bud is far from plants, bud fullness. Remove the lower leaves, 3-4 cm in plant spacing, row spacing of 4-5 cm, inserted in the greenhouse and greenhouse pot or slotting machine, maintaining 7 ℃ -8 ℃.
wants to raise chrysanthemums, now is the time to prepare
□ article / reporter Xue Liangcheng
25 days afternoon, the reporter saw at the Baotu Spring park just attended the seminar Bian suo-jun chrysanthemum. "Chrysanthemum is not over, ready for the next year Juzhan again. Manure, selected buds, cutting, pinching, watering, fertilization, pest control......" And the chrysanthemum Jieyuan 30 years, Bian master of chrysanthemum habit is familiar.
had spent many people know, will spend when transplanting, need to turn over the soil. Otherwise,[link widoczny dla zalogowanych], flower growing transplanting is poor, even will slowly die.
Bian Suojun and cultivating chrysanthemum.
if you are going to raise chrysanthemums,[link widoczny dla zalogowanych], might as well have a look Bian master keep chrysanthemum book, may help you.
a lot of people think, if the home raise chrysanthemums,[link widoczny dla zalogowanych], next spring to prepare not too late, "in fact, prepared from should now." Bian said that the master.
's teacher told reporters, the ordinary people home if raise chrysanthemums, first of all to choose the varieties of chrysanthemum, "to the general desk chrysanthemum, it is characterized by short,[link widoczny dla zalogowanych], large flowers, long flowering period, ornamental strong." Ten classic famous chrysanthemum tradition includes: Green Peony, chrysanthemum, handsome flag, red green clothes, ten Zhang curtain, Liu Yue,[link widoczny dla zalogowanych], West Lake Phoenix Zhenyu, Huangshi public, Yuhu spring etc.. These are suitable for family support, in addition, some rare species of chrysanthemum, such as purple Xia Qiuying,[link widoczny dla zalogowanych], Wulong Nao Hai Jinlong now, claw, which is found in the Baotu Spring chrysanthemum. People at home can also keep "Chrysanthemum morifolium,[link widoczny dla zalogowanych]," suggests that many species of chrysanthemum.
Bian teacher reminds say, keep the chrysanthemum is the same reason. In the process of cultivating chrysanthemum, early is the key stage in the foundation,[link widoczny dla zalogowanych], in addition to (
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Prosecution officials are studying the coalition's plan to see to what extent it violates the law. Lee Tae-ho, coordinator for the coalition, said that they would still campaign against any person on the submitted lists who runs as a candidate.

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By James L. Hendrix
See all Articles by James HendrixSee James Hendrix's Expert PageGet Updates on Anger ManagementGet Updates on James Hendrix Average: 4.25 Your rating: None Average: 4,[link widoczny dla zalogowanych].3 (4 votes) Tweet
3) People will turn part of their body or their whole body away – either to run away or to regroup for an attack,[link widoczny dla zalogowanych]. Do not push this person – back off and give them space.
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6) The pitch of the voice goes lower. Watch out! This may be a sign of an impending attack! Little dogs yap big dogs growl,[link widoczny dla zalogowanych].
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Eye rolling is considered the universal sign for contempt but it is also a sign that the person you are talking to is overwhelmed and not taking what you are saying seriously.
2) If the other person looks away, perhaps closing their eyes at the same time, they are telling you that they are flooded, overwhelmed, or angry. People look away to think as well,[link widoczny dla zalogowanych], but beware.
So here we go:
1) If the other person closes their eyes they are likely telling you that they have heard enough and can’t deal with much more. Not a blink, but closing the eyes for a second or more. This is a subtle sign that most people don’t even think about.
5) The pitch of the voice gets higher,[link widoczny dla zalogowanych], when people are stressed and on the defensive. Again this is a clear sign that they are overwhelmed.
Pay attention to these cues take them as warning that you are pushing too hard for the person you are talking to – when people have melt-downs it is not good – tears,[link widoczny dla zalogowanych], yelling, violence – all can result and none of them are productive. So now you have a list of cues that can help you know when it is time to take a time out and regroup. By the way,[link widoczny dla zalogowanych], never say YOU NEED A TIME OUT! Always say,[link widoczny dla zalogowanych], I need a time out because I am getting overwhelmed and this relationship is too important to me to try to communicate when I might say or do something I would regret and don’t really mean. And I know that the last statement doesn’t work for some guy in a bar but the warning signs could save your life.
Flooded is that condition when the heart rate and blood pressure is high and the brain function in the prefrontal cortex is dropping fast – it is the place where you say and do things that you wish you hadn’t. This is not a place to have a conversation or a relationship from. The following is not intended to prepare you to fight although you could use them as cues that you need to be ready. This is intended to allow you to take in information that the other person is giving you –letting you know that they are not really listening and if you push them, you will likely end up in an argument at best. A confrontation is likely and when the PFC turns off people do things that they regret, often.
10) If it gets to tension in the hands either hands shaking or clenched in fists back off quick,[link widoczny dla zalogowanych].
4) The voice gets louder. Okay no surprise here, we all know that, but remember it is not “knowing it” that helps – it is putting that knowing into practice that helps you.
9) Verbal cues like grunts and sighs mean something – pay attention to them,[link widoczny dla zalogowanych].
I have talked about getting people to listen, time outs and the rules of engagement. Today I am going to give you ten signs that the person you are talking to is flooded or overwhelmed and if they don’t calm down there may be trouble. They are at least not listening to you. Some of these you know but some may be new and give you an invaluable key to keeping your conversations productive. Remember you can not have a productive conversation with someone who is overwhelmed.
7) Facial expressions are a dead giveaway,[link widoczny dla zalogowanych], if you are paying attention. Scowls, wide eyed, squinting eyes are just a few warning signs that someone is overwhelmed. Don’t ignore it, and don’t push them.
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About one in 10 people with CMT1A have a new genetic mutation.
Because CMT is an ongoing condition, it is useful to be aware of the mechanics behind the condition to help prevent secondary complications developing. As always, prevention is better than treatment.
1 . Dominant (autosomal dominant)
If you have a dominant form of CMT (regardless of your sex), you have a 50:50 chance of passing on the faulty gene to any children. If they inherit it, they will usually develop the symptoms of CMT at some point during their life. If they don’t inherit it, they cannot pass CMT onto their children, as they don’t carry the abnormal gene.
Author's Bio:
The exact symptoms that you may experience may vary hugely from other people with CMT – even within your own family. This is because there are many different genetic factors within individuals that influence the CMT genes. And it is perfectly possible that you may never have any symptoms, as anywhere between one in 10 and one in five people with CMT will never have any symptoms. (Some people may only get symptoms later in life, even if they have a type that ‘normally’ shows symptoms by the teenage years.)
If secondary problems do develop, such as severely arched feet or weak ankles, then orthotics, surgery, pain management, counselling and other adaptations or aids (eg, wheelchairs) may be helpful.
If both parents are carriers for the same recessive gene, their children have a one in four chance of developing CMT (by inheriting two copies of the gene) and a 50 per cent chance of being carriers (by inheriting one copy of the gene).
If you only have one faulty recessive gene you are known as a carrier .You will not have CMT, but you have a 50:50 chance of passing on your faulty gene to your children. If they inherit it, they will only get CMT if they inherit a second faulty gene from the other parent.
CMTX is a variation of CMT1 and CMT2. It is called ‘X’ because the gene that causes this form of CMT is carried on the X chromosome. It usually affects men much more severely than women because a man has only one X chromosome and women have two. Men will usually develop symptoms beginning in late childhood or adolescence. Women may be completely unaffected, in which case they tend to be known as "carriers"; or they may be affected; but usually not as severely as males.
As at February 2006, 21 genes have been found to cause different types of CMT. Each one of these genes is responsible for making particular proteins that are essential to the axon or myelin sheaths.
Through a combination of exercise, healthy eating, physiotherapy, occupational therapy and orthotics, the aim is to stop the primary symptoms of CMT developing into major secondary problems. Or limiting the way you live your life by causing problems such as having difficulty walking,[link widoczny dla zalogowanych], back strain, difficulty handling things or uncomfortable ulcers on your feet.
In order for you to move with speed and precision,[link widoczny dla zalogowanych], messages have to be relayed between your brain and the rest of your body within a fraction of a second. These messages are relayed through your nerves.
For example, if you want to move your leg, an electrical message is sent from your brain, via the spinal cord, to the muscles in your leg along a motor nerve. If you cut or burn your leg, you feel it because an electrical signal is sent from the affected area, up the sensory nerves,[link widoczny dla zalogowanych], via the spinal cord, to your brain.
The nerves in your arms and legs, called peripheral nerves, can be compared to electrical cables. The central ‘wire’ is known as the axon and the ‘plastic outer’ is called the myelin sheath.
Axons transmit the electrical signals to and from the brain, and myelin sheath acts as insulation,[link widoczny dla zalogowanych], speeding up the signal and nourishing the central axon. Some forms of CMT affect the axon – making the signal to and from the brain weaker and less efficient. Other forms of CMT affect the myelin sheath, slowing down the signal. But even if the myelin is the problem, until there is damage to the axon there will be no symptoms of CMT. Without an intact axon and myelin sheath, your nerves are unable to activate target muscles or relay sensory information from your limbs back to the brain.
Charcot-Marie-Tooth Disease (CMT) is a condition that damages your peripheral nerves. These nerves are responsible for passing on commands from your brain to your muscles (motor nerves) and for passing information to the brain about sensations, such as pain, heat, cold and touch (sensory nerves).
Because of the nerve damage, people with CMT may find that some of their muscles become slowly weaker over the years, particularly in their feet and hands. And some people find that their sense of feeling becomes duller, or numb,[link widoczny dla zalogowanych], in the same areas.
2. Treat any problems quickly
CMT is an acronym for Charcot-Marie-Tooth, the surnames of the three doctors that first described CMT in 1886: Frenchmen Jean-Martin Charcot and Pierre Marie; and Howard Henry Tooth from the UK.
What causes CMT?
The different types of CMT
DI-CMT
The most common forms of CMT in the UK are dominant, including most forms of CMT1 and CMT2.
Good general advice is to look for the least invasive way to treat your problems using a combination of the following:
CMT is caused by a genetic fault (mutation) that leads to damage of the nerves in your legs or arms.
All types tend to produce fairly similar symptoms.
If your CMT is caused by two faulty recessive genes, you will definitely pass on one of your faulty genes to your children. But unless they inherit the same faulty gene from the other parent, they will only be a carrier.
Other key points about CMT are that it:
• Is hardly ever life threatening,[link widoczny dla zalogowanych], but often becomes slowly worse over the years – ie, it is progressive
• affects people very differently, even in the same family
• can cause the muscles in the foot, lower leg, hand and forearm to get weaker (waste)
• can cause foot drop walking gait, foot bone abnormalities (eg high arches and hammer toes), problems with hand function, balance problems, occasional lower leg and forearm muscle cramping, and loss of some normal reflexes
• may cause long-term pain and tiredness (fatigue)
• is usually passed on from parent to child
• affects all ethnic groups throughout the world
• is the focus of major genetic research, bringing us close to answering the CMT enigma.
One faulty gene responsible for CMT has been discovered on the X chromosome. Men who get X-linked CMT are often more severely affected than women .A woman who is a carrier of X-linked CMT has a 50% chance of passing the gene onto her sons, and daughters will have a 50% chance of being a carrier (and could be mildly affected).
Of our 23 pairs of chromosomes, the 23rd pair is known as the sex chromosomes – either an X or a Y .If you inherit two X chromosomes you become a woman and if you inherit an X and a Y you become a man.
3 . X-linked
Some forms of CMT1 have an earlier age of onset and these forms used to be called HMSN3 in the old classification,[link widoczny dla zalogowanych]. Two of these forms are called Dejerine Sottas disease (DSD) and Congenital Hypomyelinating Neuropathy (CHN).
CMT has many other names, the most common being:
2. Physical therapies
• Physiotherapy.
• Orthotics – the use of splints to support the joints
• Occupational therapy.
• Podiatry.
There are two other variations of CMT1 and CMT2, known as:
CMTX
DI-CMT
3. Surgery
A consultant neurologist in partnership with your GP (general practitioner) should oversee your treatment.
You may have heard of other types of CMT, including CMT3 and CMT4 for example. Because of our better understanding of the genetic causes of CMT, we now know that all of these ‘different’ types are in fact simply variations of the two main types – demyelinating and axonal.
2 . Recessive (autosomal recessive)
Hereditary motor and sensory neuropathy (HMSN) – so called because it is passed on through families (hereditary) and affects both the motor and sensory nerves (neuropathy)
CMT1 is the most common form of CMT (six out of ten people with CMT will have CMT1A), affecting the nerve’s insulating myelin sheath. CMT 1A is caused by a duplication on chromosome 17 – instead of the usual two copies of the relevant gene, there are three. This type can be detected by a blood test that is now widely available in the UK.
Rarely, people with CMT can develop more severe symptoms .These can include:
• severe problems with mobility, necessitating the use of a wheelchair
• a severe curve of the spine (scoliosis)
• speech and swallowing difficulties
• some difficulty breathing, particularly at night.
By CMT United Kingdom
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4 . “De novo” mutation
DI stands for ‘dominant intermediate’ and this form of CMT is rare and usually has similar symptoms as the common versions of CMT1 and CMT2. The reason it is called intermediate is that both the myelin sheath and the axon are damaged equally.
For both CMT1 and CMT2 there are many different subtypes and you may hear about CMT1A or CMT2AR, for example .These are all different genetic variations of the main types.
Early symptoms may include:
• slight difficulty walking because of problems picking up the feet (foot drop)
• children may experience difficulty with running and general agility before any other noticeable symptoms – including being “clumsy”
• high arches (some people will have abnormally flat feet), weak ankles and curled toes
• weakness in the hand and forearms, although the feet are usually affected first.
Other symptoms can include:
• some loss of feeling in the feet, lower legs, hands and forearms, although this is rarely troublesome
• loss of fine control in the hands,[link widoczny dla zalogowanych], making it difficult to write, do fiddly things or open jars, for example
• some muscle tremor
• tiredness (fatigue) because of the extra effort needed to do daily activities
• slight curve to the spine
• increased difficulty walking – aids may be needed, such as orthoses and walking sticks
• hip or knee problems.
Treating your CMT
Genes can change (mutate) ‘out of the blue’. If this happens then with future generations will be exposed to the risk of inheriting the changed gene in just the same way as described above.
People with CMT1 will usually notice symptoms developing in childhood or adolescence (usually between the ages of five and 15. NB ,[link widoczny dla zalogowanych].Age of onset can be earlier or sometimes later than stated)
1. Prevent unnecessary problems
What does CMT stand for?
The aim of all of these treatment options is two fold:
There are two main types of CMT:
1. Self-management
• Stretching and exercise.
• Healthy eating.
The term sporadic is used when someone with CMT has apparently no family history (ie no other family members affected). This can be due to either a “de novo” mutation as explained above or because there are no other family members around to examine to see if they may be affected.
You can inherit CMT in one of the following ways:
• if one parent has a dominant form of CMT
• if both parents are carriers of, or have, a recessive form of CMT
• if your mother has X-linked CMT
• if you are female and your father has X-linked CMT
• by a new mutation of the gene .(“de novo” mutation)
If a faulty gene is recessive it means that you need two copies of the same faulty gene (one from each parent) before you could develop CMT.
Axonal CMT (CMT2)
Demyelinating CMT (CMT1)
Summary of inheritance
Some forms of both CMT1 and CMT2 are recessive.
5 . Sporadic CMT
1. Demyelinating (CMT1) – this form of CMT affects the myelin sheath that insulates the central axon,[link widoczny dla zalogowanych].
2. Axonal (CMT2) – this form of CMT affects the central axon,[link widoczny dla zalogowanych].
The symptoms of CMT
Today the term CMT is the most commonly used, although HMSN is still used in some medical literature.
At present, there is no specific treatment or cure for the underlying genetic cause of CMT. Neither are there any drugs to stop or reverse the damage caused to the peripheral nerves.
But, although there is no cure for CMT, there are a number of treatments available. These can slow the development, or ease, some of the secondary complications linked to CMT, greatly improving your quality of life.
CMT2 is not as common as CMT1, but has similar symptoms. Rather than damaging the nerves’ insulating myelin sheath, CMT2 affects the axon. Because of this CMT2 is also known as ‘axonal CMT’.
Symptoms are often first noticed between the ages of 10 and 20.
CMTX
Inheritance patterns
Some faulty genes are dominant, which means that you only need one faulty gene to cause CMT .In effect the dominant gene overwrites the instructions from the ‘good’ gene.
Peroneal muscular atrophy (PMA) – so called because one of the muscles that is often first affected, becoming weaker and wasted (atrophied) is called the peroneus muscle,[link widoczny dla zalogowanych], found in the shin.
Passing on our Genes and CMT
In the UK, some 25,000 people are thought to have CMT (approx 1:2500) making it the most common inherited neurological condition.
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Energy therapy and conventional therapy diverge when the actual energy healing process begins. If you are going to use energy healing techniques, then work with the energy that is in and around your body. The BodyTalk System and similar techniques restore your energy's natural flow by clearing it.
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Healing with energy therapy is gentle but it can be powerfully effective as far as desired results go. Some people progress rapidly and will notice a difference in the first session. For others,[link widoczny dla zalogowanych], results will come slower. Your life will completely turn around when you see the results that come from energy therapy.
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Ten Tips for Acknowledging
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9. Learn to watch and listen with a sense of gratitude.
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“Sawu Bona” is a South African greeting which literally means,[link widoczny dla zalogowanych], “I see you.” Its deeper meaning is “because you are there, I exist,” that “without each other, we literally do not exist.” Imagine what your workplace would be like if this acknowledgement was genuinely sent and received on a daily basis.
By Patricia Morgan
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Appreciation is undervalued by many organizations while being a key ingredient for a thriving workplace. This is the conclusion from countless management experts and research projects. In How Full is Your Bucket? Positive Strategies for Work and Life,[link widoczny dla zalogowanych], Tom Rath and Dr. Donald Clifton said that the main reason most North Americans leave their jobs is that they don’t feel appreciated. Their conclusions also include:
• Sixty-five percent of Americans received no recognition at work last year.
• Five positive interactions are needed to counteract one negative interaction.
We all crave to be seen, heard and acknowledged. Whether I say that to individuals, groups or large audiences, heads nod in the affirmative. When I first began working in a counseling agency,[link widoczny dla zalogowanych], I was thrilled with the supervision. My manager smiled,[link widoczny dla zalogowanych], nodded and listened as I worked out my problems through non-stop, extroverted talking. As I exited from his office, I would turn, thank him for his time and he would respond with a generous laugh and a big “You’re most welcome.” I left notes of appreciation on his desk and the occasional homemade muffin. I was surprised,[link widoczny dla zalogowanych], therefore,[link widoczny dla zalogowanych], when I learned that long-time employees felt frustrated by his lack of wise guidance. The lesson? Acknowledgement and a sense of gratitude improve working conditions whether it is sent or received by employees or management.
Author's Bio:
Appreciation has the biggest impact when it is given randomly. B.F. Skinner discovered that random reinforcement more strongly anchors behaviors than consistent reward. Consider how we view bosses who arrange a surprise on Administrative Assistants’ Day compared to a boss who for no reason acts with a gesture of appreciation. It’s similar to gestures of affection in intimate relationships. Compare the romantic scale of a single rose gifted on Valentine’s Day with one given on an ordinary day.
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Jaypee Garden Isles: Think ahead for blissful Living
Jaypee Greens is a pioneer real estate company which is known for its residential developments. This time, they have come up with Jaypee Garden Isles in the heart of Noida. This newly launched project is one of the most beautiful architectural designs of Noida.
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